2. Anti-infection Autophagy Apoptosis
  3. HIV ULK Bcl-2 Family
  4. 13-Oxyingenol-13-dodecanoate

13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM.13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis.

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13-Oxyingenol-13-dodecanoate Chemical Structure

13-Oxyingenol-13-dodecanoate Chemical Structure

CAS No. : 54706-70-6

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13-Oxyingenol-13-dodecanoate Related Antibodies

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Description

13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM[1].13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis[2].

In Vitro

13-Oxyingenol-dodecanoate (0, 3.125, 6.25, 12.5, 25 and 50 µM, 72 h) significantly reduces A549, H460, and BEAS-2B cells cell proliferation[2].
13-Oxyingenol-dodecanoate (0, 5, 10 and 20 µM, 72 h) can inhibit the antiapoptotic protein BCL-2 and increasing the pro-apoptotic protein BAX in NSCLC cells[2].
13-Oxyingenol-dodecanoate (0, 5, 10 and 20 µM, 72 h) influences the effect on the intracellular redox state redox state, 13-Oxyingenol-dodecanoate leads to a loss of mitochondrial membrane potential, 13-Oxyingenol-dodecanoate causes concentration-dependent mitochondrial dysfunction in A549 and H460 cells[2].
13-Oxyingenol-dodecanoate (0, 5, 10 and 20 µM, 72 h) induces significant up-regulation of ATG5, degradation of p62, and dose-dependent conversion of LC3 I to LC3 II. 13-Oxyingenol-dodecanoate induces concentration-dependent autophagy in A549 and H460 cells[2].
13-Oxyingenol-dodecanoate (0, 5, 10 and 20µ M, 72 h) significantly increased the expression of ULK1 in NSCLC cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

13-Oxyingenol-13-dodecanoate Related Antibodies

Cell Viability Assay[2]

Cell Line: A549 and H460 cells
Concentration: 0, 3.125, 6.25, 12.5, 25, and 50 µM
Incubation Time: 72 h
Result: Increased significantly the antitumor activity of A549 and H460 cells.

Western Blot Analysis[2]

Cell Line: A549 and H460 cells
Concentration: 0, 5, 10, 20 µM
Incubation Time: 72 h
Result: Induced significant up-regulation of ATG5, degradation of p62, and dose-dependent conversion of LC3 I to LC3 II.
In Vivo

13-Oxyingenol-dodecanoate (2.5 mg/kg and 5 mg/kg; ip; every two days for two weeks) significantly inhibites the growth of transplanted tumors in a xenograft model by injecting H460 cells subcutaneously into nude mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: xenograft model by injecting H460 cells into nude mice [2]
Dosage: 2.5 mg/kg and 5 mg/kg; every two days for two weeks
Administration: Intraperitoneal injection (i.p.)
Result: nhibited the growth of transplanted tumors in nude mice and had no significant toxic effects on organ function.
Molecular Weight

546.74

Formula

C32H50O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCC(O[C@@]12C[C@@H](C)[C@@](C=C(C)[C@@H]3O)(C4=O)[C@]3(O)[C@H](O)C(CO)=C[C@@]4([H])[C@]1([H])C2(C)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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13-Oxyingenol-13-dodecanoate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

13-Oxyingenol-13-dodecanoate54706-70-6HIVULKBcl-2 FamilyHuman immunodeficiency virusUnc-51 like kinaseAnti-HIVNon-small cell lung cancerULK1 InducerA549 and H460 cellsInhibitorinhibitorinhibit

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