2. Autophagy Others NF-κB
  3. Autophagy Keap1-Nrf2 Isotope-Labeled Compounds
  4. Ezetimibe-d4

Ezetimibe-d4  (Synonyms: SCH 58235-d4)

Cat. No.: HY-17376S Purity: 98.14%
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Ezetimibe-d4 is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

For research use only. We do not sell to patients.

Ezetimibe-d<sub>4</sub> Chemical Structure

Ezetimibe-d4 Chemical Structure

CAS No. : 1093659-90-5

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1 mg USD 210 In-stock
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Based on 1 publication(s) in Google Scholar

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Ezetimibe-d4 Related Antibodies

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Description

Ezetimibe-d4 is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

Molecular Weight

413.45

Formula

C24H17D4F2NO3
CAS No.
Unlabeled Cas

163222-33-1
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@H](CC[C@H](O)C2=CC=C(F)C=C2)[C@@H](C3=CC=C(O)C=C3)N1C(C([2H])=C4[2H])=C([2H])C([2H])=C4F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (483.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.24 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4187 mL 12.0934 mL 24.1867 mL
5 mM 0.4837 mL 2.4187 mL 4.8373 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4187 mL 12.0934 mL 24.1867 mL 60.4668 mL
5 mM 0.4837 mL 2.4187 mL 4.8373 mL 12.0934 mL
10 mM 0.2419 mL 1.2093 mL 2.4187 mL 6.0467 mL
15 mM 0.1612 mL 0.8062 mL 1.6124 mL 4.0311 mL
20 mM 0.1209 mL 0.6047 mL 1.2093 mL 3.0233 mL
25 mM 0.0967 mL 0.4837 mL 0.9675 mL 2.4187 mL
30 mM 0.0806 mL 0.4031 mL 0.8062 mL 2.0156 mL
40 mM 0.0605 mL 0.3023 mL 0.6047 mL 1.5117 mL
50 mM 0.0484 mL 0.2419 mL 0.4837 mL 1.2093 mL
60 mM 0.0403 mL 0.2016 mL 0.4031 mL 1.0078 mL
80 mM 0.0302 mL 0.1512 mL 0.3023 mL 0.7558 mL
100 mM 0.0242 mL 0.1209 mL 0.2419 mL 0.6047 mL
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Ezetimibe-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ezetimibe-d41093659-90-5SCH 58235-d4AutophagyKeap1-Nrf2Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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