2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. G-744

G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis.

For research use only. We do not sell to patients.

G-744 Chemical Structure

G-744 Chemical Structure

CAS No. : 1346669-54-2

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G-744 Related Antibodies

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Description

G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis[1].

IC50 & Target

IC50: 2 nM (Btk), 64 nM (CD86)[1].
In Vivo

G-744 (6.25/12.25/25 mg/kg, p.o., b.i.d., daily) protects Lewis rats from collagen-induced arthritis dose-dependently[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Lewis rat based CIA models[1].
Dosage: 6.25, 12.25, 25 mg/kg.
Administration: Orally, b.i.d., daily for 17 days.
Result: All three doses resulted in a significant dose-dependent inhibition of ankle thickness between day 10 and day 17 (onset of increase in ankle diameter on day 9).
Molecular Weight

527.64

Formula

C29H29N5O3S
CAS No.
Unlabeled CAS

SMILES

CN(C1=O)C=C(C2=CC=CC(N3C(C(SC4=C5CC(C)(C)C4)=C5CC3)=O)=C2CO)C=C1NC6=CC=NC=N6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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G-744 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G-7441346669-54-2G744G 744BtkBruton tyrosine kinaseInhibitorinhibitorinhibit

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HY-102036
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