2. Metabolic Enzyme/Protease
  3. Tryptophan Hydroxylase
  4. LP-533401

LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.

For research use only. We do not sell to patients.

LP-533401 Chemical Structure

LP-533401 Chemical Structure

CAS No. : 945976-43-2

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Solution
10 mM * 1 mL in DMSO USD 116 In-stock
Solid
1 mg USD 50 In-stock
5 mg USD 100 In-stock
10 mg USD 150 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
100 mg USD 610 In-stock
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Based on 3 publication(s) in Google Scholar

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LP-533401 Related Antibodies

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Description

LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.

IC50 & Target

Tryptophan hydroxylase[1]
In Vitro

LP-533401 completely inhibits serotonin production in Tph1–expressing cells (RBL2H3 cells) at a dose of 1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LP-533401 Related Antibodies
In Vivo

Oral administration once daily for up to 6 weeks of this small molecule prevents the development of and fully rescues, in a dose-dependent manner, osteoporosis in ovariectomized rodents because of an isolated increase in bone formation. Pharmacokinetic studies in rodents show that LP-533401 level in the brain is negligible following oral administration, indicating that it is virtually unable to cross the blood-brain barrier[1]. Mice treated repeatedly with LP-533401 (30–250 mg/kg per day) exhibit marked 5-HT content reductions in the gut, lungs, and blood, but not in the brain. After a single LP533401 dose (250 mg/kg), lung and gut 5-HT contents decrease by 50%, whereas blood 5-HT levels remain unchanged, suggesting gut and lung 5-HT synthesis[2]. Adult, healthy mice treated with the Tph-1 inhibitor LP-533401 show 30% decrease in circulating serotonin levels, with a consequent 30% increase in osteoblast numbers. Administration of LP533401 to mice injected with EL4 cells inhibits the decrement in osteoblast numbers and trabecular bone volume, prolongs survial, and decreases leukemic infiltration[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

526.48

Formula

C27H22F4N4O3
CAS No.
Unlabeled Cas

Appearance

Solid

Color

Brown to breen

SMILES

N[C@@H](CC1=CC=C(C2=NC(N)=NC(OC(C3=CC=C(C4=CC=CC(F)=C4)C=C3)C(F)(F)F)=C2)C=C1)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation

Purity: 98.68%

COA (251 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[1]

Mice: Mice are treated from day 1 post-ovariectomy for 4 weeks with LP-533401 (1, 10, 100 or 250 mg per kg body weight per day) or vehicle. Next mice are treated for 4 weeks starting 2 weeks post-ovariectomy with LP-533401 (250 mg per kg body weight per day) or vehicle. lastly, mice are treated for 6 weeks starting 6 weeks post-ovariectomy with LP-533401 (25, 100 or 250 mg per kg body weight per day) or vehicle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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LP-533401 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LP-533401945976-43-2LP533401LP 533401Tryptophan HydroxylaseInhibitorinhibitorinhibit

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