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  4. Simaroubaceae

Simaroubaceae

 

Simaroubaceae (60):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19543
    Brusatol 14907-98-3 99.89%
    Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent. Brusatol increases cellular apoptosis.
    Brusatol
  • HY-N1943
    Ailanthone 981-15-7 99.76%
    Ailanthone (Δ13-Dehydrochaparrinone) is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69 nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309 nM).
    Ailanthone
  • HY-N3014
    Bruceine D 21499-66-1 99.53%
    Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity. Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L.
    Bruceine D
  • HY-N0840
    Bruceantin 41451-75-6 99.94%
    Bruceantin(NSC165563) is first isolated from Brucea javanica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.
    Bruceantin
  • HY-N0841
    Bruceine A 25514-31-2 98.01%
    Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.
    Bruceine A
  • HY-N2926
    β-Carboline-1-propionic acid 89915-39-9
    β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent.
    β-Carboline-1-propionic acid
  • HY-N12875
    Ailancoumarin E
    Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC50 of 14.21 μM.
    Ailancoumarin E
  • HY-N12838
    Glycerol-2-(3-methoxy-4-hydroxybenzoicacid)ether 80677-81-2
    Glycerol-2-(3-methoxy-4-hydroxybenzoicacid)ether is a phenolic derivative and can be isolated from Picrasma quassioides (D. Don) Benn.
    Glycerol-2-(3-methoxy-4-hydroxybenzoicacid)ether
  • HY-111806
    3,7,4'-Trihydroxyflavone 2034-65-3 99.44%
    3,7,4'-Trihydroxyflavone, isolated from Rhus javanica var. roxburghiana, is a flavonoid with DNA strand-scission activity.
    3,7,4'-Trihydroxyflavone
  • HY-N8146
    Bruceantinol 53729-52-5 98.89%
    Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc.
    Bruceantinol
  • HY-N1581
    Quassin 76-78-8 ≥98.0%
    Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity.
    Quassin
  • HY-N3013
    Bruceine B 25514-29-8 99.60%
    Bruceine B inhibits protein synthesis and nucleic acid synthesis.
    Bruceine B
  • HY-N4210
    Yadanziolide A 95258-14-3 99.41%
    Yadanziolide A, isolated from the cultivated dry seeds of Brucea javanica, has strong antiviral activities with IC50 of 5.5 μM against tobacco mosaic virus. Yadanziolide A shows significant antitumor effects.
    Yadanziolide A
  • HY-N10450
    Kumujian A 72755-19-2 98.32%
    Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC50 = 4.87 μg/mL) and elastase release (IC50 = 6.29 μg/mL).
    Kumujian A
  • HY-N10926
    (+)-Glaucarubinone 1259-86-5
    (+)-Glaucarubinone is a potent AP-1 (activator protein-1) inhibitor with an EC50 value of 0.13 µM. (+)-Glaucarubinone shows noncytotoxic.
    (+)-Glaucarubinone
  • HY-N1203
    (5α)-Stigmastane-3,6-dione 22149-69-5
    (5α)-Stigmastane-3,6-dione is a naturally occurring sterol that could be isolated from fruits of Ailanthus altissima Swingle. Antimicrobial Activity..
    (5α)-Stigmastane-3,6-dione
  • HY-N2128
    Nigakinone 18110-86-6 99.95%
    Nigakinone is one of the most abundant alkaloids responsible for the major pharmacological activities of Kumu.
    Nigakinone
  • HY-N3015
    Bruceine E 21586-90-3
    Bruceine E is a quassinoid from seeds of Brucea javanica (L.) Merr, exhibiting hypoglycemia effect. Bruceine E exhibits blood glucose lowering effect in both nondiabetic mice and Streptozotocin (STZ)-induced diabetic rats at lower dose.
    Bruceine E
  • HY-N3710
    Dehydrocrenatidine 65236-62-6 ≥98.0%
    Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain.
    Dehydrocrenatidine
  • HY-N4257
    Yadanzioside A 95258-15-4 ≥98.0%
    Yadanziolide A, a quassinoid glycoside from Brucea javanica, has antitumor activity.
    Yadanzioside A