2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-132987
    Avibactam tomilopil
    		Inhibitor 99.66%
    Avibactam tomilopil (ARX-1796, AV-006), an Avibactam proagent, is an orally bioavailable β-lactamase inhibitor. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemase (KPC) enzymes.
    Avibactam tomilopil
  • HY-B1275A
    Cephalothin
    		Inhibitor 99.69%
    Cephalotin (Cephalotin) is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM.
    Cephalothin
  • HY-19964
    Potassium clavulanate cellulose
    		Inhibitor ≥98.0%
    Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is a bacterial β-lactamase inhibitor. Clavulanate potassium is a form of Clavulanic acid. Clavulanate potassium fights bacteria that resistant to penicillins and other antibiotics. Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.
    Potassium clavulanate cellulose
  • HY-B0593A
    Ceftazidime pentahydrate
    		Inhibitor 98.84%
    Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.
    Ceftazidime pentahydrate
  • HY-105284
    Sulopenem
    		Inhibitor 99.70%
    Sulopenem (CP-70429) is an orally active, parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria. Sulopenem has the potential for urinary tract infections and intra-abdominal infections treatment. Sulopenem is inactive against Pseudomonas aeruginosa and Xanthomonas maltophilia.
    Sulopenem
  • HY-B1434
    7-Aminocephalosporanic acid
    		Inhibitor ≥98.0%
    7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor.
    7-Aminocephalosporanic acid
  • HY-B0466B
    Cloxacillin sodium
    		Inhibitor 98.03%
    Cloxacillin sodium is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 µM. Cloxacillin sodium can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins.
    Cloxacillin sodium
  • HY-B1256A
    Cefuroxime
    		Inhibitor
    Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria.
    Cefuroxime
  • HY-16745
    Lascufloxacin
    		Inhibitor 98.04%
    Lascufloxacin (KRP-AM1977X) is a potent and orally active fluoroquinolone antibacterial agent. Lascufloxacin potently inhibits infections caused by various pathogens, including quinolone-resistant strains. Lascufloxacin has the potential for various infectious diseases treatment, including lower respiratory tract infections.
    Lascufloxacin
  • HY-150758
    NDM-1 inhibitor-3
    		Inhibitor 99.41%
    NDM-1 inhibitor-3 (Compound 89) is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor with a Ki of 4 μM.
    NDM-1 inhibitor-3
  • HY-154438
    RDR 02308
    		Inhibitor ≥98.0%
    RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase.
    RDR 02308
  • HY-108062A
    BLI-489 hydrate
    		Inhibitor ≥99.0%
    BLI-489 hydrate, a penem β-lactamase inhibitor, is active against class A and class C as well as some class D β-lactamases. The combination of Piperacillin and BLI-489 hydrate is efficacious against murine infections caused by class A (including extended-spectrum β-lactamases), class C (AmpC), and class D β-lactamase-expressing pathogens.
    BLI-489 hydrate
  • HY-136306
    Metallo β-lactamase ligand 1
    		Inhibitor 99.60%
    Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A.
    Metallo β-lactamase ligand 1
  • HY-129629
    Thiomandelic acid
    		Inhibitor
    Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases.
    Thiomandelic acid
  • HY-16980
    Eravacycline
    		Inhibitor
    Eravacycline is a potent and broad-spectrum antibacterial agent.
    Eravacycline
  • HY-147274
    Funobactam
    		Inhibitor
    Funobactam (XNW4107) is a β-lactamase inhibitor, can be used for researching anti-bacteria.
    Funobactam
  • HY-N2359
    Chelerythrine
    		Inhibitor
    Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.
    Chelerythrine
  • HY-139745A
    FPI-1523
    		Inhibitor
    FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity.
    FPI-1523
  • HY-108288
    Sulbactam pivoxil
    		Inhibitor ≥98.0%
    Sulbactam pivoxil is a proagent of sulbactam. Sulbactam is a β-lactamase inhibitor which poorly adsorbed from gastrointestinal tract. Sulbactam pivoxil has a better absorption than the parent agent and provides high serum levels after oral administration.
    Sulbactam pivoxil
  • HY-12826
    IMB-XH1
    		Inhibitor ≥98.0%
    IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1). IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively.
    IMB-XH1
Beta-lactamase Isoform Comparison

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