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  4. Abciximab

Abciximab  (Synonyms: C7E3)

Cat. No.: HY-P9934 Purity: 99.966%
COA

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Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors.

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Abciximab Chemical Structure

Abciximab Chemical Structure

CAS No. : 143653-53-6

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Abciximab Related Antibodies

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Description

Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors[1].

In Vitro

Abciximab (C7E3) inhibits platelet aggregation induced by physiologic and pathologic agonists by binding to the platelet αIIbβ3 integrin[2].
Abciximab appears to have similar affinity for the αIIbβ3 and αvβ3 integrins and redistributes between them[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Abciximab Related Antibodies
In Vivo

Abciximab (C7E3) (0.25 mg/kg/day; i.v.; 28 days) effectively prevents neointimal hyperplasia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 200-250 g, balloon angioplasty model[2]
Dosage: 0.25 mg/kg/day
Administration: Intravenous injection, 28 days
Result: Time-dependently inhibited both neointimal hyperplasia and lumen occlusion after angioplasty in carotid arteries of rats. Significantly reduced PDGF-BB expression in vessel lumens and neointimal smooth muscle cells after angioplasty. Suppressed the elevation of plasma TxB2 concentration.
Clinical Trial
CAS No.
Unlabeled CAS

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Abciximab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.966%

COA (291 KB)

Handling Instructions (2659 KB)
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Abciximab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abciximab143653-53-6C7E3Integringlycoprotein IIb/IIIaplatelet aggregationleucocyte adhesionvitronectinMac-1neointimal hyperplasiaInhibitorinhibitorinhibit

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