2. Immunology/Inflammation Epigenetics Metabolic Enzyme/Protease
  3. COX Histone Acetyltransferase Endogenous Metabolite
  4. Acetaminophen-d3

Acetaminophen-d3  (Synonyms: Paracetamol-d3; 4-Acetamidophenol-d3; 4'-Hydroxyacetanilide-d3)

Cat. No.: HY-66005S1 Purity: ≥99.0%
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Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

For research use only. We do not sell to patients.

Acetaminophen-d<sub>3</sub> Chemical Structure

Acetaminophen-d3 Chemical Structure

CAS No. : 60902-28-5

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Based on 1 publication(s) in Google Scholar

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Acetaminophen-d3 Related Antibodies

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Description

Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acetaminophen-d3 Related Antibodies
Molecular Weight

154.18

Formula

C8H6D3NO2
CAS No.
Unlabeled CAS

103-90-2
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=C(O)C=C1)C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1621.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (64.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4859 mL 32.4296 mL 64.8593 mL
5 mM 1.2972 mL 6.4859 mL 12.9719 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 6.4859 mL 32.4296 mL 64.8593 mL 162.1481 mL
5 mM 1.2972 mL 6.4859 mL 12.9719 mL 32.4296 mL
10 mM 0.6486 mL 3.2430 mL 6.4859 mL 16.2148 mL
15 mM 0.4324 mL 2.1620 mL 4.3240 mL 10.8099 mL
20 mM 0.3243 mL 1.6215 mL 3.2430 mL 8.1074 mL
25 mM 0.2594 mL 1.2972 mL 2.5944 mL 6.4859 mL
30 mM 0.2162 mL 1.0810 mL 2.1620 mL 5.4049 mL
40 mM 0.1621 mL 0.8107 mL 1.6215 mL 4.0537 mL
50 mM 0.1297 mL 0.6486 mL 1.2972 mL 3.2430 mL
60 mM 0.1081 mL 0.5405 mL 1.0810 mL 2.7025 mL
DMSO 80 mM 0.0811 mL 0.4054 mL 0.8107 mL 2.0269 mL
100 mM 0.0649 mL 0.3243 mL 0.6486 mL 1.6215 mL
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Acetaminophen-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acetaminophen-d360902-28-5Paracetamol-d34-Acetamidophenol-d34'-Hydroxyacetanilide-d3COXHistone AcetyltransferaseEndogenous MetaboliteCyclooxygenaseHATsHATInhibitorinhibitorinhibit

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