[Ala17]-MCH TFA 

[Ala17]-MCH TFA, a MCH analogue (HY-P1525A), is a selective ligand for MCHR₁ (K_i=0.16 nM) over MCHR₂ (K_i=34 nM). [Eu³⁺ chelate-labeled [Ala17]-MCH shows high affnity for MCHR₁ (K_d=0.37 nM) while has little demonstrable binding affnity for MCHR₂^[1].

Ki: 0.16 nM (MCHR1)
Ki: 34 nM (MCHR2)^[1]

2385.73

C₉₉H₁₅₆F₃N₂₉O₂₈S₄

Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Ala-Gln-Val (Disulfide bridge:Cys7-Cys16)

DFDMLRCMLGRVYRPCAQV (Disulfide bridge:Cys7-Cys16)

OC(C(F)(F)F)=O.O=C1N2C(CCC2)([H])C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCCNC(N)=N)=O)CC3=CC=C(C=C3)O)=O)C(C)C)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CCSC)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xiaoying Gao, et al. Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal Biochem. 2004 May 15;328(2):187-95.  [Content Brief]