2. Others Metabolic Enzyme/Protease Autophagy
  3. Isotope-Labeled Compounds Glucosidase Autophagy
  4. Ambroxol-d5 hydrochloride

Ambroxol-d5 hydrochloride  (Synonyms: NA-872-d5 hydrochloride)

Cat. No.: HY-B1039AS Purity: 99.46%
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Ambroxol-d5 (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

For research use only. We do not sell to patients.

Ambroxol-d<sub>5</sub> hydrochloride Chemical Structure

Ambroxol-d5 hydrochloride Chemical Structure

CAS No. : 2741380-71-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Ambroxol-d5 hydrochloride:

Ambroxol-d5 hydrochloride Related Antibodies

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Description

Ambroxol-d5 (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ambroxol-d5 hydrochloride Related Antibodies
Molecular Weight

419.59

Formula

C13H14D5Br2ClN2O
CAS No.
Unlabeled Cas

23828-92-4
Appearance

Solid

Color

White to off-white

SMILES

O[C@@](C([2H])([2H])C1)([2H])C([2H])([2H])C[C@@H]1NCC2=C(C(Br)=CC(Br)=C2)N.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (47.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 20 mg/mL (47.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3833 mL 11.9164 mL 23.8328 mL
5 mM 0.4767 mL 2.3833 mL 4.7666 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 2.3833 mL 11.9164 mL 23.8328 mL 59.5820 mL
5 mM 0.4767 mL 2.3833 mL 4.7666 mL 11.9164 mL
10 mM 0.2383 mL 1.1916 mL 2.3833 mL 5.9582 mL
15 mM 0.1589 mL 0.7944 mL 1.5889 mL 3.9721 mL
20 mM 0.1192 mL 0.5958 mL 1.1916 mL 2.9791 mL
25 mM 0.0953 mL 0.4767 mL 0.9533 mL 2.3833 mL
30 mM 0.0794 mL 0.3972 mL 0.7944 mL 1.9861 mL
40 mM 0.0596 mL 0.2979 mL 0.5958 mL 1.4895 mL
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Ambroxol-d5 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ambroxol-d52741380-71-0NA-872-d5Isotope-Labeled CompoundsGlucosidaseAutophagyInhibitorinhibitorinhibit

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