2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Amosulalol

Amosulalol  (Synonyms: YM 09538)

Cat. No.: HY-106720 Purity: 98.69%
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Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR).

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Amosulalol Chemical Structure

Amosulalol Chemical Structure

CAS No. : 85320-68-9

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Based on 1 publication(s) in Google Scholar

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Description

Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR)[1].

IC50 & Target[1]

α1-adrenergic receptor

 

Beta-1 adrenergic receptor

 

In Vivo

Amosulalol (3-30 mg/kg; p.o.; single dose) reduces acute systolic blood pressure in hypertensive rats[1].
Amosulalol (50 mg/kg; p.o.; twice daily for 12 weeks) produces an intolerant antihypertensive effect and also reduces central rate and increases PRA in hypertensive rat models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

380.46

Formula

C18H24N2O5S
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

NS(=O)(C1=CC(C(O)CNCCOC2=C(C=CC=C2)OC)=CC=C1C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Amosulalol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amosulalol85320-68-9YM 09538YM09538YM-09538Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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