Angiogenin Fragment (108-123) 

Angiogenin Fragment (108-123) is a C-terminal segment 108-123 of Angiogenin that inhibits the enzymatic and biological activities of Angiogenin^[1].

Angiogenin Fragment (108-123) inhibits the initial rate of degradation of tRNA catalyzed by angiogenin in a concentration dependent manner yielding an apparent K_i value of 278 μM. Angiogenin Fragment (108-123) also inhibits nuclease activity of angiogenin when tRNA is the substrate. Furthermore, Angiogenin Fragment (108-123) significantly decreases neovascularization elicited by angiogenin in the chick chorioallantoic membrane assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1878.10

C₈₃H₁₃₂N₂₆O₂₄

112173-48-5

ENGLPVHLDQSIFRRP

CC[C@@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC(CNC([C@@H](NC([C@@H](N)CCC(O)=O)=O)CC(N)=O)=O)=O)CC(C)C)=O)=O)C(C)C)=O)CC2=CN=CN2)=O)CC(C)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CO)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC4=CC=CC=C4)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. S M Rybak, et al. C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin. Biochem Biophys Res Commun. 1989 Jul 14;162(1):535-43.  [Content Brief]