2. Immunology/Inflammation
  3. PGE synthase COX
  4. Anti-inflammatory agent 78

Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line.

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Anti-inflammatory agent 78 Chemical Structure

Anti-inflammatory agent 78 Chemical Structure

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Anti-inflammatory agent 78 Related Antibodies

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Description

Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line[1].

IC50 & Target

COX-1

 

COX-2

 

In Vitro

Anti-inflammatory agent 78 (compound L-37) has a high tumor cell growth inhibitory ability at 10 μM along with a significant effect on the growth of RAW 264.7 cells[1].
Anti-inflammatory agent 78 (1-10 μM, 24 h) inhibits LPS-induced PGE2 synthesis in RAW 264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 78 Related Antibodies

Cell Viability Assay[1]

Cell Line: RAW 264.7 cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 h
Result: Inhibited LPS-induced PGE2 synthesis in a dosedependent manner. Inhibited the PGF1 production as well as the expression of COX-1, but displayed weak inhibition activity towards the Leukotrienes (LT) and Thromboxane-B2 (TXB-2) production.
In Vivo

Anti-inflammatory agent 78 (compound L-37) (25-100 mg/kg, IP) displayed remarkable in-vivo anti-inflammatory activity via the xylene-induced mice ear edema model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (xylene-induced mice ear edema model)[1]
Dosage: 100 mg/kg
Administration: IP
Result: Exhibited a dose-dependent anti-inflammatory effect in vivo. L-37 has a slightly weaker inhibitory activity than celecoxib (HY-14398) in animal models, it also shows good activity and a nearly 78.14% inhibition rate at the dosage of 50 mg/kg.
Molecular Weight

355.77

Formula

C19H14ClNO4
SMILES

OC(C1=CC=C(Cl)C=C1N2CC3=CC=CC=C3)(C#CC(OC)=O)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 78 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 78PGE synthaseCOXProstaglandin E synthaseCyclooxygenasePGE2Anti-inflammatoryRAW 264.7 cellInhibitorinhibitorinhibit

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Anti-inflammatory agent 78
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HY-162425
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