2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Apoptosis
  3. Phosphatase PI3K TNF Receptor
  4. AQX-016A

AQX-016A is an orally active and potent SHIP1 agonist. AQX-016A can activate recombinant SHIP1 enzyme in vitro and stimulate SHIP1 activity. AQX-016A also can inhibit the PI3K pathway and TNFa production, can be useful for various inflammatory diseases research.

For research use only. We do not sell to patients.

AQX-016A Chemical Structure

AQX-016A Chemical Structure

CAS No. : 849669-54-1

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5 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

AQX-016A Related Antibodies

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Description

AQX-016A is an orally active and potent SHIP1 agonist. AQX-016A can activate recombinant SHIP1 enzyme in vitro and stimulate SHIP1 activity. AQX-016A also can inhibit the PI3K pathway and TNFa production, can be useful for various inflammatory diseases research[1][2].

IC50 & Target

CD40

 

PI3K

 

In Vitro

AQX-016A (5 μg/mL, 30 min) inhibits the PI3K-mediated increase in intracellular PIP3 levels, and reduces PIP3 levels through activation of a 5 'phosphatase enzyme[1].
AQX-01 6A (0-5 μg/mL, 30 min) inhibits LPS-induced PKB phosphorylation in a SHIP dependent manner[1].
AQX-016A (0-5 μg/mL, 2 h) significantly inhibits TNFa in both J774 and peritoneal macrophages at both 1 and 5 μg/mL[1].
AQX-016A (0-6 μg/mL, 30 min) requires SHIP to maximally inhibit TNFa production in BMDM, selectively inhibits TNF production from SHIP1+/+ but not SHIP1-/- macrophages[1].
AQX-016A (0-5 μg/mL, 0-90 min) inhibits TNFa translation[1].
AQX-016A (0-15 μM, 30 min) increases SHIP1 enzyme activity in vitro and in intact cells, inhibits macrophage and mast-cell activation[2].
AQX-016A (15 μM, 30 min) inhibits immune cell activation, and inhibits PI3K-dependent macrophage and mast-cell responses in a SHIP-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AQX-016A Related Antibodies

Western Blot Analysis

Cell Line: SHIP1+/+ and SHIP1-/- mast cells[2]
Concentration: 0, 3, 6, 15, 30 μM
Incubation Time: 30 min
Result: Inhibited PIP3-regulated intracellular signal transduction events in SHIP-expressing hematopoietic cells, but not in SHIP-deficient hematopoietic or nonhematopoietic cells. Preferentially inhibited, in a dose-dependent manner, LPS-stimulated PKB phosphorylation in SHIP1+/+ but not in SHIP1-/-macrophages, and inhibited the phosphorylation of PKB, p38MAPK and extracellular signal-regulated kinase (ERK) in SHIP1+/+ but not in SHIP1-/- mast cells.
In Vivo

AQX-016A (20 mg/kg, Orally, once) significantly inhibits plasma TNFa levels, and inhibits inflammation in a mouse model endotoxemia[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

328.49

Formula

C22H32O2
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

OC1=C(O)C2=C(C(C)=C1)[C@]3(C)CC[C@](C(C)(C)CCC4)([H])[C@@]4(C)[C@@]3([H])C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 66 mg/mL (200.92 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0442 mL 15.2212 mL 30.4423 mL
5 mM 0.6088 mL 3.0442 mL 6.0885 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.00%

COA (253 KB) HNMR (245 KB) RP-HPLC (133 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.0442 mL 15.2212 mL 30.4423 mL 76.1058 mL
5 mM 0.6088 mL 3.0442 mL 6.0885 mL 15.2212 mL
10 mM 0.3044 mL 1.5221 mL 3.0442 mL 7.6106 mL
15 mM 0.2029 mL 1.0147 mL 2.0295 mL 5.0737 mL
20 mM 0.1522 mL 0.7611 mL 1.5221 mL 3.8053 mL
25 mM 0.1218 mL 0.6088 mL 1.2177 mL 3.0442 mL
30 mM 0.1015 mL 0.5074 mL 1.0147 mL 2.5369 mL
40 mM 0.0761 mL 0.3805 mL 0.7611 mL 1.9026 mL
50 mM 0.0609 mL 0.3044 mL 0.6088 mL 1.5221 mL
60 mM 0.0507 mL 0.2537 mL 0.5074 mL 1.2684 mL
80 mM 0.0381 mL 0.1903 mL 0.3805 mL 0.9513 mL
100 mM 0.0304 mL 0.1522 mL 0.3044 mL 0.7611 mL
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AQX-016A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AQX-016A849669-54-1PhosphatasePI3KTNF ReceptorPhosphoinositide 3-kinaseTumor Necrosis Factor ReceptorTNFROrally activeInflammatory diseasesSepticemiamantle cell lymphoma (MCL)Hematopoietic malignancies multiple myelomaEndotoxemiaInhibitorinhibitorinhibit

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