2. Others Anti-infection
  3. Isotope-Labeled Compounds Parasite
  4. Artemether-d3

Artemether-d3  (Synonyms: Dihydroqinghaosu methyl ether-d3; Dihydroartemisinin methyl ether-d3; SM224-d3)

Cat. No.: HY-N0402S Purity: ≥99.0%
COA Handling Instructions

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Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.

For research use only. We do not sell to patients.

Artemether-d<sub>3</sub> Chemical Structure

Artemether-d3 Chemical Structure

CAS No. : 93787-85-0

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1 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Artemether-d3:

Artemether-d3 Related Antibodies

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  • Purity & Documentation

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Description

Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.

IC50 & Target

Plasmodium

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Artemether-d3 Related Antibodies
Molecular Weight

301.39

Formula

C16H23D3O5
CAS No.
Unlabeled CAS

71963-77-4
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@@H]1OC([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (331.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3180 mL 16.5898 mL 33.1796 mL
5 mM 0.6636 mL 3.3180 mL 6.6359 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3180 mL 16.5898 mL 33.1796 mL 82.9490 mL
5 mM 0.6636 mL 3.3180 mL 6.6359 mL 16.5898 mL
10 mM 0.3318 mL 1.6590 mL 3.3180 mL 8.2949 mL
15 mM 0.2212 mL 1.1060 mL 2.2120 mL 5.5299 mL
20 mM 0.1659 mL 0.8295 mL 1.6590 mL 4.1474 mL
25 mM 0.1327 mL 0.6636 mL 1.3272 mL 3.3180 mL
30 mM 0.1106 mL 0.5530 mL 1.1060 mL 2.7650 mL
40 mM 0.0829 mL 0.4147 mL 0.8295 mL 2.0737 mL
50 mM 0.0664 mL 0.3318 mL 0.6636 mL 1.6590 mL
60 mM 0.0553 mL 0.2765 mL 0.5530 mL 1.3825 mL
80 mM 0.0415 mL 0.2074 mL 0.4147 mL 1.0369 mL
100 mM 0.0332 mL 0.1659 mL 0.3318 mL 0.8295 mL
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Artemether-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Artemether-d393787-85-0Dihydroqinghaosu methyl ether-d3Dihydroartemisinin methyl ether-d3SM224-d3Isotope-Labeled CompoundsParasiteInhibitorinhibitorinhibit

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