Atorvastatin-d₅ hemicalcium

Name: Atorvastatin-d 5 hemicalcium
Brand: MedChemExpress
SKU: HY-B0589S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0589S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Atorvastatin-d₅ (hemicalcium) is the deuterium labeled Atorvastatin. Atorvastatin hemicalcium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

For research use only. We do not sell to patients.

Atorvastatin-d<sub>5</sub> hemicalcium Chemical Structure

Atorvastatin-d₅ hemicalcium Chemical Structure

CAS No. : 222412-82-0

Size	Price	Stock	Quantity
500 μg	USD 170	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 960	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Atorvastatin-d₅ hemicalcium:

Atorvastatin In-stock
(3S,5S)-Atorvastatin In-stock
Atorvastatin hemicalcium trihydrate Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

583.71

Formula

C₃₃H₃₀D₅FN₂O₅.1/2Ca

CAS No.

222412-82-0

Unlabeled Cas

134523-03-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C2=CC=C(C=C2)F)=C1C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NC4=CC=CC=C4.[Ca].[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMF : ≥ 25 mg/mL (42.83 mM)

DMSO : ≥ 15 mg/mL (25.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 0.5 mg/mL (0.86 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7132 mL	8.5659 mL	17.1318 mL
5 mM	0.3426 mL	1.7132 mL	3.4264 mL
10 mM	0.1713 mL	0.8566 mL	1.7132 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (257 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [Content Brief]

[3]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22. [Content Brief]

[4]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. [Content Brief]

[5]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72. [Content Brief]

[6]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821. [Content Brief]

[7]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMF	1 mM	1.7132 mL	8.5659 mL	17.1318 mL	42.8295 mL
	5 mM	0.3426 mL	1.7132 mL	3.4264 mL	8.5659 mL
	10 mM	0.1713 mL	0.8566 mL	1.7132 mL	4.2829 mL
	15 mM	0.1142 mL	0.5711 mL	1.1421 mL	2.8553 mL
	20 mM	0.0857 mL	0.4283 mL	0.8566 mL	2.1415 mL
	25 mM	0.0685 mL	0.3426 mL	0.6853 mL	1.7132 mL
DMF	30 mM	0.0571 mL	0.2855 mL	0.5711 mL	1.4276 mL
DMF	40 mM	0.0428 mL	0.2141 mL	0.4283 mL	1.0707 mL