2. Neuronal Signaling
  3. Amyloid-β
  4. Aβ42 agonist-1

Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells.

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Aβ42 agonist-1 Chemical Structure

Aβ42 agonist-1 Chemical Structure

CAS No. : 50635-12-6

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10 mg USD 160 In-stock
25 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

Aβ42 agonist-1 Related Antibodies

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Description

Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

IC50 & Target

Aβ42 aggregation[1]
Molecular Weight

237.25

Formula

C15H11NO2
CAS No.
Unlabeled CAS

Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(C1=CC2=C(C=CC=C2)O1)NC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (526.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2150 mL 21.0748 mL 42.1496 mL
5 mM 0.8430 mL 4.2150 mL 8.4299 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2150 mL 21.0748 mL 42.1496 mL 105.3741 mL
5 mM 0.8430 mL 4.2150 mL 8.4299 mL 21.0748 mL
10 mM 0.4215 mL 2.1075 mL 4.2150 mL 10.5374 mL
15 mM 0.2810 mL 1.4050 mL 2.8100 mL 7.0249 mL
20 mM 0.2107 mL 1.0537 mL 2.1075 mL 5.2687 mL
25 mM 0.1686 mL 0.8430 mL 1.6860 mL 4.2150 mL
30 mM 0.1405 mL 0.7025 mL 1.4050 mL 3.5125 mL
40 mM 0.1054 mL 0.5269 mL 1.0537 mL 2.6344 mL
50 mM 0.0843 mL 0.4215 mL 0.8430 mL 2.1075 mL
60 mM 0.0702 mL 0.3512 mL 0.7025 mL 1.7562 mL
80 mM 0.0527 mL 0.2634 mL 0.5269 mL 1.3172 mL
100 mM 0.0421 mL 0.2107 mL 0.4215 mL 1.0537 mL
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Aβ42 agonist-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ42 agonist-150635-12-6Amyloid-ββ-amyloid peptideAβAbetaaggregation kineticsbeta-amyloidcell viabilityfibrillogenesisfluorescence imagingmolecular dockingsmall moleculestransmission electron microscopyInhibitorinhibitorinhibit

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