Beclin1-ATG14L interaction inhibitor 1

Cat. No.: HY-156237 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

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Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport.

For research use only. We do not sell to patients.

Beclin1-ATG14L interaction inhibitor 1 Chemical Structure

CAS No. : 1243063-73-1

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10 mg		Check price and availability

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Description

Molecular Weight

468.53

Formula

C₂₃H₂₄N₄O₅S

CAS No.

1243063-73-1

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CC2=NOC(C3CCC3)=N2)C4=CC(S(=O)(NC5=CC=CC(C)=C5C)=O)=CC=C4OC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (213.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1343 mL	10.6717 mL	21.3434 mL
5 mM	0.4269 mL	2.1343 mL	4.2687 mL
10 mM	0.2134 mL	1.0672 mL	2.1343 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.88%

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Data Sheet (271 KB) SDS (251 KB)

COA (250 KB) HNMR (141 KB) RP-HPLC (168 KB) LCMS (355 KB)

Handling Instructions (2659 KB)

References

[1]. Pavlinov I, et al. Beclin 1-ATG14L Protein-Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I. J Am Chem Soc. 2020 May 6;142(18):8174-8182. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1343 mL	10.6717 mL	21.3434 mL	53.3584 mL
	5 mM	0.4269 mL	2.1343 mL	4.2687 mL	10.6717 mL
	10 mM	0.2134 mL	1.0672 mL	2.1343 mL	5.3358 mL
	15 mM	0.1423 mL	0.7114 mL	1.4229 mL	3.5572 mL
	20 mM	0.1067 mL	0.5336 mL	1.0672 mL	2.6679 mL
	25 mM	0.0854 mL	0.4269 mL	0.8537 mL	2.1343 mL
	30 mM	0.0711 mL	0.3557 mL	0.7114 mL	1.7786 mL
	40 mM	0.0534 mL	0.2668 mL	0.5336 mL	1.3340 mL
	50 mM	0.0427 mL	0.2134 mL	0.4269 mL	1.0672 mL
	60 mM	0.0356 mL	0.1779 mL	0.3557 mL	0.8893 mL
	80 mM	0.0267 mL	0.1334 mL	0.2668 mL	0.6670 mL
	100 mM	0.0213 mL	0.1067 mL	0.2134 mL	0.5336 mL