2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Belotecan-d7 hydrochloride

Belotecan-d7 (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative[1][2].

For research use only. We do not sell to patients.

Belotecan-d<sub>7</sub> hydrochloride Chemical Structure

Belotecan-d7 hydrochloride Chemical Structure

CAS No. : 1346598-22-8

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5 mg USD 1400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Belotecan-d7 hydrochloride:

Belotecan-d7 hydrochloride Related Antibodies

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Description

Belotecan-d7 (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Belotecan-d7 hydrochloride Related Antibodies
Molecular Weight

477.00

Formula

C25H21D7ClN3O4
CAS No.
Unlabeled CAS

213819-48-8
Appearance

Solid

Color

White to off-white

SMILES

O=C1N2C(C3=NC4=CC=CC=C4C(CCNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=C3C2)=CC5=C1COC([C@]5(O)CC)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (26.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0964 mL 10.4822 mL 20.9644 mL
5 mM 0.4193 mL 2.0964 mL 4.1929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥96.0%

COA (257 KB) Elemental Analysis Report (116 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0964 mL 10.4822 mL 20.9644 mL 52.4109 mL
5 mM 0.4193 mL 2.0964 mL 4.1929 mL 10.4822 mL
10 mM 0.2096 mL 1.0482 mL 2.0964 mL 5.2411 mL
15 mM 0.1398 mL 0.6988 mL 1.3976 mL 3.4941 mL
20 mM 0.1048 mL 0.5241 mL 1.0482 mL 2.6205 mL
25 mM 0.0839 mL 0.4193 mL 0.8386 mL 2.0964 mL
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Belotecan-d7 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belotecan-d71346598-22-8TopoisomeraseInhibitorinhibitorinhibit

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