6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

Definition:

Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.

References:

[1]. Song-Gun Kim, et al. A direct substrate-substrate interaction found in the kinase domain of the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. J Mol Biol. 2007 Jun 29;370(1):14-26. [Content Brief]

[2]. J Chesney, et al. An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3047-52. [Content Brief]

[3]. Song-Gun Kim, et al. Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy. J Biol Chem. 2006 Feb 3;281(5):2939-44. [Content Brief]

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