7-methylguanosine phosphate-specific 5'-nucleotidase

Definition:

Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates.

References:

[1]. Juliane Buschmann, et al. Identification of Drosophila and human 7-methyl GMP-specific nucleotidases. J Biol Chem. 2013 Jan 25;288(4):2441-51. [Content Brief]

[2]. Thomas Monecke, et al. Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP. PLoS One. 2014 Mar 6;9(3):e90915. [Content Brief]

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