CAAX prenyl protease 2

Definition:

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1.

References:

[1]. J C Otto, et al. Cloning and characterization of a mammalian prenyl protein-specific protease. J Biol Chem. 1999 Mar 26;274(13):8379-82. [Content Brief]

[2]. James F Burrows, et al. USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. J Biol Chem. 2009 Apr 3;284(14):9587-95. [Content Brief]

[3]. I Hollander, et al. Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides. Anal Biochem. 2000 Nov 1;286(1):129-37. [Content Brief]

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