Caspase recruitment domain-containing protein 10

Definition:

Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR.

References:

[1]. C Jiang, et al. TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-κB activation and tumor progression. Oncogene. 2017 May 18;36(20):2813-2823. [Content Brief]

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