Chromodomain-helicase-DNA-binding protein 3

Definition:

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Involved in transcriptional repressiobn as part of the NuRD complex. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.

References:

[1]. J K Tong, et al. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature. 1998 Oct 29;395(6705):917-21. [Content Brief]

[2]. Daisuke Yamashita, et al. Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α. J Biol Chem. 2016 May 27;291(22):11619-34. [Content Brief]

[3]. James Edward Sillibourne, et al. Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. Mol Biol Cell. 2007 Sep;18(9):3667-80. [Content Brief]

[4]. Lot Snijders Blok, et al. CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language. Nat Commun. 2018 Nov 5;9(1):4619. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.