DDB1- and CUL4-associated factor 7

Definition:

Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

References:

[1]. Kazumasa Morita, et al. HAN11 binds mDia1 and controls GLI1 transcriptional activity. J Dermatol Sci. 2006 Oct;44(1):11-20. [Content Brief]

[2]. Jianping Jin, et al. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell. 2006 Sep 1;23(5):709-21. [Content Brief]

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