Disintegrin and metalloproteinase domain-containing protein 22

Definition:

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

References:

[1]. Peng cheng Zhu, et al. The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading. Biochem Biophys Res Commun. 2003 Feb 21;301(4):991-9. [Content Brief]

[2]. Pengcheng Zhu, et al. ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3. Biochem Biophys Res Commun. 2005 Jun 17;331(4):938-46. [Content Brief]

[3]. Giovanna M D'Abaco, et al. ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain. Neurosurgery. 2006 Jan;58(1):179-86; discussion 179-86. [Content Brief]

[4]. Heli Liu, et al. Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM function. J Biol Chem. 2009 Oct 16;284(42):29077-86. [Content Brief]

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