DNA damage-regulated autophagy modulator protein 2

Definition:

Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.

References:

[1]. Sun-Mi Park, et al. Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1340-4. [Content Brief]

[2]. Mohammed E El-Asrag, et al. Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement. Am J Hum Genet. 2015 Jun 4;96(6):948-54. [Content Brief]

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