DNA-directed RNA polymerase II subunit GRINL1A

Definition:

Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.

References:

[1]. Xiaopeng Hu, et al. A Mediator-responsive form of metazoan RNA polymerase II. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9506-11. [Content Brief]

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