DNA double-strand breaks (DSB)

Definition:

DNA double-strand breaks (DSB) is among the most deleterious DNA lesions, which if unrepaired or repaired incorrectly can cause cell death or genome instability that may lead to cancer.

References:

[1]. Yang YG, Qi Y. RNA-directed repair of DNA double-strand breaks. DNA Repair (Amst). 2015 Aug;32:82-85. [Content Brief]

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