Glucagon-like peptide 1 receptor

Definition:

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).

References:

[1]. B van Eyll, et al. Signal transduction of the GLP-1-receptor cloned from a human insulinoma. FEBS Lett. 1994 Jul 4;348(1):7-13. [Content Brief]

[2]. Jesper Lau, et al. Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. J Med Chem. 2015 Sep 24;58(18):7370-80. [Content Brief]

[3]. Gaojie Song, et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 Jun 8;546(7657):312-315. [Content Brief]

[4]. Stephanie Hennen, et al. Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor. Sci Rep. 2016 May 19;6:26236. [Content Brief]

[5]. M P Graziano, et al. Cloning and functional expression of a human glucagon-like peptide-1 receptor. Biochem Biophys Res Commun. 1993 Oct 15;196(1):141-6. [Content Brief]

[6]. Christina Rye Underwood, et al. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. J Biol Chem. 2010 Jan 1;285(1):723-30. [Content Brief]

[7]. B Thorens, et al. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes. 1993 Nov;42(11):1678-82. [Content Brief]

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