Glycoprotein hormones alpha chain

Definition:

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

References:

[1]. Xuliang Jiang, et al. Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer. J Biol Chem. 2014 May 16;289(20):14273-82. [Content Brief]

[2]. J L Keene, et al. Expression of biologically active human follitropin in Chinese hamster ovary cells. J Biol Chem. 1989 Mar 25;264(9):4769-75. [Content Brief]

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