Interferon-induced protein 44-like

Definition:

Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity. During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion. Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate. Exhibits a low antiviral activity against hepatitis C virus. Acts also as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5.

References:

[1]. Haiqin Jiang, et al. IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses. J Immunol Res. 2021 Oct 20;2021:5599408. [Content Brief]

[2]. Marta L DeDiego, et al. Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses. J Virol. 2019 Oct 15;93(21):e01159-19. [Content Brief]

[3]. John W Schoggins, et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011 Apr 28;472(7344):481-5. [Content Brief]

[4]. D C Busse, et al. Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus. J Virol. 2020 Aug 31;94(18):e00297-20. [Content Brief]

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