Lariat debranching enzyme

Definition:

Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem.

References:

[1]. Ying Ye, et al. DBR1 siRNA inhibition of HIV-1 replication. Retrovirology. 2005 Oct 18;2:63. [Content Brief]

[2]. Shen-Ying Zhang, et al. Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell. 2018 Feb 22;172(5):952-965.e18. [Content Brief]

[3]. J W Kim, et al. Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants. Nucleic Acids Res. 2000 Sep 15;28(18):3666-73. [Content Brief]

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