Lipopolysaccharide-responsive and beige-like anchor protein

Definition:

Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria.

References:

[1]. Thanh Ngoc Nguyen, et al. ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system. Mol Cell. 2021 May 6;81(9):2013-2030.e9. [Content Brief]

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