Palmitoyltransferase ZDHHC6

Definition:

Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation.

References:

[1]. Laurence Abrami, et al. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. Elife. 2017 Aug 15;6:e27826. [Content Brief]

[2]. Deniz Senyilmaz, et al. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Sep 3;525(7567):124-8. [Content Brief]

[3]. Asvin Kk Lakkaraju, et al. Palmitoylated calnexin is a key component of the ribosome-translocon complex. EMBO J. 2012 Apr 4;31(7):1823-35. [Content Brief]

[4]. Maria Fairbank, et al. RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase. FEBS Lett. 2012 Jul 30;586(16):2488-93. [Content Brief]

[5]. Gregory J Fredericks, et al. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16478-83. [Content Brief]

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