Parathyroid carcinoma

Definition:

Parathyroid carcinoma (PC) is a highly aggressive endocrine tumor, with an annual incidence of less than 1 per million. Over 90% of patients present with excess parathyroid hormone (PTH), representing

References:

[1]. B Givi, et al. Parathyroid carcinoma. Clin Oncol (R Coll Radiol). 2010 Aug;22(6):498-507. [Content Brief]

[2]. F Cetani, et al. Update on parathyroid carcinoma. J Endocrinol Invest. 2016 Jun;39(6):595-606. [Content Brief]

[3]. Fiona McClenaghan, et al. Parathyroid cancer. Gland Surg. 2015 Aug;4(4):329-38. [Content Brief]

[4]. Janneke E Witteveen, et al. Downregulation of CASR expression and global loss of parafibromin staining are strong negative determinants of prognosis in parathyroid carcinoma. Mod Pathol. 2011 May;24(5):688-97. [Content Brief]

[5]. Jessica Costa-Guda, et al. Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors. Mol Cell Endocrinol. 2014 Apr 5;386(1-2):46-54. [Content Brief]

[6]. Kai Duan, et al. Parathyroid Carcinoma: Diagnosis and Clinical Implications. Turk Patoloji Derg. 2015;31 Suppl 1:80-97. [Content Brief]

[7]. Peter P Truran, et al. Parafibromin, galectin-3, PGP9.5, Ki67, and cyclin D1: using an immunohistochemical panel to aid in the diagnosis of parathyroid cancer. World J Surg. 2014 Nov;38(11):2845-54. [Content Brief]

[8]. Serap Karaarslan, et al. The Role of Parafibromin, Galectin-3, HBME-1, and Ki-67 in the Differential Diagnosis of Parathyroid Tumors. Oman Med J. 2015 Nov;30(6):421-7. [Content Brief]

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