Patient-derived xenograft models (PDX)

Definition:

Patient-derived xenograft models (PDX) is a xenograft model, which fresh tumor tissue or tumor cells from a patient are transplanted in situ or ectopic into immunodeficient mice and grown in the environment provided by the mice.PDX is widely used as preclinical cancer models, which represents the genomic features of primary tumors.

References:

[1]. Uri Ben-David, et al. Patient-derived xenografts undergo mouse-specific tumor evolution. Nat Genet. 2017 Nov;49(11):1567-1575. [Content Brief]

[2]. Jiahao Shi, et al. The fidelity of cancer cells in PDX models: Characteristics, mechanism and clinical significance. Int J Cancer. 2020 Apr 15;146(8):2078-2088. [Content Brief]

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