Peroxisomal membrane protein PEX16

Definition:

Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3.

References:

[1]. Peter K Kim, et al. The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER. J Cell Biol. 2006 May 22;173(4):521-32. [Content Brief]

[2]. Masanori Honsho, et al. The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly. J Biol Chem. 2002 Nov 15;277(46):44513-24. [Content Brief]

[3]. K A Sacksteder, et al. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J Cell Biol. 2000 Mar 6;148(5):931-44. [Content Brief]

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