Peroxisome assembly protein 26

Definition:

Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes. PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane.

References:

[1]. Satomi Furuki, et al. Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex. J Biol Chem. 2006 Jan 20;281(3):1317-23. [Content Brief]

[2]. Chika Nashiro, et al. Recruiting mechanism of the AAA peroxins, Pex1p and Pex6p, to Pex26p on the peroxisomal membrane. Traffic. 2011 Jun;12(6):774-88. [Content Brief]

[3]. Naomi Matsumoto, et al. The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes. Nat Cell Biol. 2003 May;5(5):454-60. [Content Brief]

[4]. Shigehiko Tamura, et al. Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p. J Biol Chem. 2006 Sep 22;281(38):27693-704. [Content Brief]

[5]. André Halbach, et al. Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites. J Cell Sci. 2006 Jun 15;119(Pt 12):2508-17. [Content Brief]

[6]. Naomi Matsumoto, et al. Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation. Am J Hum Genet. 2003 Aug;73(2):233-46. [Content Brief]

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