Phorbol-12-myristate-13-acetate-induced protein 1

Definition:

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

References:

[1]. Jie Han, et al. Functional linkage between NOXA and Bim in mitochondrial apoptotic events. J Biol Chem. 2007 Jun 1;282(22):16223-31. [Content Brief]

[2]. E Oda, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000 May 12;288(5468):1053-8. [Content Brief]

[3]. Peter E Czabotar, et al. Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. [Content Brief]

[4]. Yaping Sun, et al. Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection. J Biol Chem. 2005 Apr 22;280(16):15561-8. [Content Brief]

[5]. Lin Chen, et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005 Feb 4;17(3):393-403. [Content Brief]

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