Phosphatidate cytidylyltransferase 2

Definition:

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid. Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis.

References:

[1]. Kenneth D'Souza, et al. Distinct properties of the two isoforms of CDP-diacylglycerol synthase. Biochemistry. 2014 Dec 2;53(47):7358-67. [Content Brief]

[2]. Yanfei Qi, et al. CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. J Lipid Res. 2016 May;57(5):767-80. [Content Brief]

[3]. Yanqing Xu, et al. CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. J Biol Chem. 2019 Nov 8;294(45):16740-16755. [Content Brief]

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