Phosphatidylinositol 3-kinase catalytic subunit type 3

Definition:

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity).; (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication.

References:

[1]. Mary-Pat Stein, et al. Human VPS34 and p150 are Rab7 interacting partners. Traffic. 2003 Nov;4(11):754-71. [Content Brief]

[2]. Bao-Cun Zhang, et al. STEEP mediates STING ER exit and activation of signaling. Nat Immunol. 2020 Aug;21(8):868-879. [Content Brief]

[3]. Caroline G Williams, et al. Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication. Cell Rep. 2021 Aug 3;36(5):109479. [Content Brief]

[4]. S Volinia, et al. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J. 1995 Jul 17;14(14):3339-48. [Content Brief]

[5]. Antonia P Sagona, et al. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol. 2010 Apr;12(4):362-71. [Content Brief]

[6]. Yu-Hsuan Chen, et al. VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism. Nat Commun. 2021 Feb 26;12(1):1322. [Content Brief]

[7]. Sigrid B Thoresen, et al. A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp Cell Res. 2010 Dec 10;316(20):3368-78. [Content Brief]

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