Phosphatidylinositol transfer protein beta isoform

Definition:

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function.

References:

[1]. Sadaf Shadan, et al. Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells. Traffic. 2008 Sep;9(10):1743-56. [Content Brief]

[2]. Y Fullwood, et al. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta. J Biol Chem. 1999 Oct 29;274(44):31553-8. [Content Brief]

[3]. Nicolas Carvou, et al. Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum. J Cell Sci. 2010 Apr 15;123(Pt 8):1262-73. [Content Brief]

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