Phosphoserine phosphatase

Definition:

Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine (Probable).

References:

[1]. J Jaeken, et al. Phosphoserine phosphatase deficiency in a patient with Williams syndrome. J Med Genet. 1997 Jul;34(7):594-6. [Content Brief]

[2]. Maria Veiga-da-Cunha, et al. Mutations responsible for 3-phosphoserine phosphatase deficiency. Eur J Hum Genet. 2004 Feb;12(2):163-6. [Content Brief]

[3]. Yves Peeraer, et al. How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase. Eur J Biochem. 2004 Aug;271(16):3421-7. [Content Brief]

[4]. J B Vincent, et al. Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan. Clin Genet. 2015 Mar;87(3):296-8. [Content Brief]

[5]. Hye-Yeon Kim, et al. Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. J Biol Chem. 2002 Nov 29;277(48):46651-8. [Content Brief]

[6]. Veeranna, et al. Phosphoserine phosphatase of human brain: partial purification, characterization, regional distribution, and effect of certain modulators including psychoactive drugs. Neurochem Res. 1990 Dec;15(12):1203-10. [Content Brief]

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