PIN2/TERF1-interacting telomerase inhibitor 1

Definition:

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.

References:

[1]. Jian Lin, et al. Characterization of a novel effect of hPinX1 on hTERT nucleolar localization. Biochem Biophys Res Commun. 2007 Feb 23;353(4):946-52. [Content Brief]

[2]. Kai Yuan, et al. PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation. J Biol Chem. 2009 Aug 21;284(34):23072-82. [Content Brief]

[3]. Jeong Eun Yoo, et al. Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres. J Mol Biol. 2009 May 22;388(5):928-40. [Content Brief]

[4]. Soma S R Banik, et al. Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR. J Biol Chem. 2004 Dec 10;279(50):51745-8. [Content Brief]

[5]. Na Li, et al. PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression. Biochem Biophys Res Commun. 2009 Jun 19;384(1):76-81. [Content Brief]

[6]. Bin Zhang, et al. Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells. Cancer Res. 2009 Jan 1;69(1):75-83. [Content Brief]

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