Plakophilin-1

Definition:

Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis. May facilitate the formation of intermediate filaments.

References:

[1]. J A McGrath, et al. Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome. Nat Genet. 1997 Oct;17(2):240-4. [Content Brief]

[2]. I Hofmann, et al. Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. J Cell Sci. 2000 Jul;113 ( Pt 13):2471-83. [Content Brief]

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