Plasmanylethanolamine desaturase

Definition:

Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms.

References:

[1]. Aránzazu Gallego-García, et al. A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis. Science. 2019 Oct 4;366(6461):128-132. [Content Brief]

[2]. Ernst R Werner, et al. The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7792-7798. [Content Brief]

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