Pleckstrin homology domain-containing family M member 2

Definition:

Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.

References:

[1]. Jing Pu, et al. BORC, a multisubunit complex that regulates lysosome positioning. Dev Cell. 2015 Apr 20;33(2):176-88. [Content Brief]

[2]. Cláudia Rosa-Ferreira, et al. Arl8 and SKIP act together to link lysosomes to kinesin-1. Dev Cell. 2011 Dec 13;21(6):1171-8. [Content Brief]

[3]. Emmanuel Boucrot, et al. The intracellular fate of Salmonella depends on the recruitment of kinesin. Science. 2005 May 20;308(5725):1174-8. [Content Brief]

[4]. Rituraj Marwaha, et al. The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes. J Cell Biol. 2017 Apr 3;216(4):1051-1070. [Content Brief]

[5]. Amit Tuli, et al. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Mol Biol Cell. 2013 Dec;24(23):3721-35. [Content Brief]

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