Plexin-B3

Definition:

Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.

References:

[1]. Stefania Artigiani, et al. Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep. 2004 Jul;5(7):710-4. [Content Brief]

[2]. X Li, et al. Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. Oncogene. 2012 Feb 2;31(5):595-610. [Content Brief]

[3]. Xinhua Li, et al. Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. J Biol Chem. 2010 Oct 15;285(42):32436-45. [Content Brief]

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