Polycystic kidney disease 2-like 1 protein

Definition:

Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration. The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription. Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells. The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again. May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity).

References:

[1]. Raymond E Hulse, et al. Cryo-EM structure of the polycystin 2-l1 ion channel. Elife. 2018 Jul 13;7:e36931. [Content Brief]

[2]. Yong Yu, et al. Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun. 2012;3:1252. [Content Brief]

[3]. Wang Zheng, et al. A novel PKD2L1 C-terminal domain critical for trimerization and channel function. Sci Rep. 2015 Mar 30;5:9460. [Content Brief]

[4]. X Z Chen, et al. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature. 1999 Sep 23;401(6751):383-6. [Content Brief]

[5]. Paul G DeCaen, et al. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12;504(7479):315-8. [Content Brief]

[6]. Wang Zheng, et al. Regulation of TRPP3 Channel Function by N-terminal Domain Palmitoylation and Phosphorylation. J Biol Chem. 2016 Dec 2;291(49):25678-25691. [Content Brief]

[7]. Qiang Li, et al. The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. FEBS Lett. 2002 Apr 10;516(1-3):270-8. [Content Brief]

[8]. Wang Zheng, et al. Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2. Cell Rep. 2018 Feb 6;22(6):1560-1573. [Content Brief]

[9]. Taufiqul Huque, et al. Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue. PLoS One. 2009 Oct 8;4(10):e7347. [Content Brief]

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